Identification and Characterization of TRO19622 (Cholest-4-en-3- One, Oxime), a Novel Drug Candidate for Amyotrophic Lateral Sclerosis
نویسندگان
چکیده
Trophos, Parc Scientifique de Luminy case 931, 13288 Marseille cedex 9, France (T.B., B.B., M.M., C.D., P.G., P.D., E.S., D.M., M.D., R.M.P.) ; Washington University School of Medicine, Saint Louis, MO, USA (N.P.A., A.S.E., D.F.C.); U773 Inserm, Centre de Recherche Biologique Bichat Beaujeon (CRB3), Université Paris 7, Faculté de Médecine Bichat, 16 rue Henri Huchard, BP 416, 75018 Paris, France (M.A.O., J-J.L.); UMR 788 Inserm, Université Paris 11, 80 rue du Général Leclerc, 94276 Le Kremlin-Bicêtre, cedex, France (C.M., M.S.); and UMR623 Inserm, Parc Scientifique de Luminy, 13288 Marseille, France, Present address, Center for Motor Neuron Biology and Disease, Columbia University, New York, USA (C.E.H.) JPET Fast Forward. Published on May 11, 2007 as DOI:10.1124/jpet.107.123000
منابع مشابه
Identification and characterization of cholest-4-en-3-one, oxime (TRO19622), a novel drug candidate for amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder characterized by progressive death of cortical and spinal motor neurons, for which there is no effective treatment. Using a cell-based assay for compounds capable of preventing motor neuron cell death in vitro, a collection of approximately 40,000 low-molecular-weight compounds was screened to identify potential small-mol...
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Diabetes and cancer chemotherapies are often associated with painful neuropathy. The mechanisms underlying neuropathic pain remain poorly understood, and the current therapies have limited efficacy and are associated with dose-limiting side effects. We recently described the pharmacological characterization of cholest-4-en-3-one, oxime (TRO19622), a cholesterol-like compound, that significantly...
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Olesoxime (TRO19622) is a novel mitochondrial-targeted neuroprotective compound undergoing a pivotal clinical efficacy study in Amyotrophic Lateral Sclerosis (ALS) and also in development for Spinal Muscular Atrophy (SMA). It belongs to a new family of cholesterol-oximes identified for its survival-promoting activity on purified motor neurons deprived of neurotrophic factors. Olesoxime targets ...
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